Research Fellow

**Job Description**
The Research Fellow will undertake advanced analysis and validation experiments within the MRC BioFlare research programme, focusing on understanding synovial mechanisms underlying rheumatoid arthritis (RA) flare. This involves integrating and interpreting single-cell RNAseq, Hyperion IMC, and Xenium spatial transcriptomic data to identify cellular/molecular parameters predicting RA flare and to delineate specific pathobiological pathways. The role also includes validating mechanistic hypotheses using in vitro techniques, contributing to funding generation, collaborating with partners, and publishing research findings in high-impact journals.

**Skills & Abilities**
• High level analytical capability
• Ability to communicate complex information clearly
• Full working knowledge of informatic environments including R
• Understanding of and ability to contribute to broader management/administration processes
• Ability to contribute to the planning and organising of the research programme and/or specific research project
• Ability to coordinate own work with others to avoid conflict or duplication of effort
• Knowledge of the protected characteristics of the Equality Act 2010

**Qualifications**
Required Degree(s) in:
• Biological Science (First class degree)

**Experience**
Experience Required:
• Extensive experience and fluency in analysis of single cell RNAseq data
• Extensive experience of spatial analytic techniques including segmentation, annotation and clustering
• Hands on experience of dealing with 10x Xenium spatial transcriptomic data
• Experience of working in industry
• Experience of cell phenotyping, cytometry and cell sorting techniques including FACS, MACS and flow cytometry

Note: We’ve analyzed the actual job post using AI, for more details visit the original job post by clicking on “Apply Now”!