**Job Description**
This Postdoctoral Researcher position in the Wang Lab at MCW focuses on the structural and functional analysis of oncogenic noncoding RNAs. The role involves utilizing a multidisciplinary approach, integrating biochemical, biophysical, and structural biology techniques (including NMR, X-ray crystallography, and cryo-EM) to explore RNA structure-function relationships and identify opportunities for RNA-targeted therapeutic intervention in cancer and related diseases.
**Skills & Abilities**
• Hands-on experience in at least one structural biology technique (e.g., NMR spectroscopy, X-ray crystallography, cryo-EM)
• Strong background in RNA biology or nucleic acid biochemistry
• Proven ability to work independently, manage time effectively, and troubleshoot experiments
• Experience with RNA preparation and purification
• Familiarity with RNA structural probing methods (e.g., SHAPE, DMS mapping, RNase digestion)
• Experience in protein expression, purification, and RNA-protein complex reconstitution
• Exposure to small-molecule screening or RNA-targeted drug discovery
• Strong publication record in peer-reviewed journals
**Qualifications**
Required Degree(s) in:
• Biochemistry
• Biophysics
• Structural Biology
• Chemistry
• Molecular Biology
• Related discipline
**Experience**
Experience Required:
• Hands-on experience in at least one structural biology technique (e.g., NMR spectroscopy, X-ray crystallography, cryo-EM)
Other:
• Strong background in RNA biology or nucleic acid biochemistry
• Proven ability to work independently, manage time effectively, and troubleshoot experiments
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