Research Fellow

**Job Description**
This position involves advanced analysis and validation experiments within the MRC BioFlare research programme, which focuses on understanding synovial mechanisms underlying disease flare in Rheumatoid Arthritis (RA). The role requires integrating transcriptomic and spatial proteomic data from advanced technologies like 10x Chromium single cell sequencing, IMC, and Xenium spatial transcriptomics. The Research Fellow will identify measurable synovial tissue cellular/molecular parameters predicting RA flare, delineate pathobiological pathways, validate mechanistic hypotheses using in vitro techniques, and publish findings in high-impact journals.

**Skills & Abilities**
• High level analytical capability.
• Ability to communicate complex information clearly.
• Full working knowledge of informatic environments including R.
• Extensive experience and fluency in analysis of single cell RNAseq data.
• Extensive experience of spatial analytic techniques including segmentation, annotation and clustering.
• Hands on experience of dealing with 10x Xenium spatial transcriptomic data.
• Experience of cell phenotyping, cytometry and cell sorting techniques including FACS, MACS and flow cytometry.
• Understanding of and ability to contribute to broader management/administration processes.
• Ability to contribute to the planning and organising of the research programme and/or specific research project.
• Ability to co-ordinate own work with others to avoid conflict or duplication of effort.
• Knowledge of the protected characteristics of the Equality Act 2010.

**Qualifications**
Required Degree(s) in:
• Biological Science

**Experience**
Other:
• Experience of working in industry

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