**Job Description**
The Dalebroux lab investigates how Bacteroides outer membrane vesicles (OMVs) directly and indirectly contribute to protection against Clostridiodes difficile (Cdif) infection within the human intestine. The central hypothesis is that Bacteroides respond to environmental signals and the presence of Cdif by deploying OMVs carrying contents that antagonize Cdif toxin production and growth, while promoting beneficial immune responses to prevent Cdif expansion. This position involves employing techniques in bacteriology, biochemistry, molecular biology, eukaryotic cell culture, and genetics to define environmental signals cueing specific OMV production and discern bacterial molecules within these OMVs that influence gut homeostasis and dysbiosis during health and disease related to Cdif infection. The role includes assisting research staff in collecting data, conducting literature searches, technical research, analyzing data, and preparing reports with minimal supervision.
**Skills & Abilities**
• Working knowledge of how to safely handle and dispose of biohazardous materials or chemicals following Federal, State, and University regulations and guidelines.
• Detail oriented.
• Ability to analyze data and keep records.
• Ability to communicate verbally and in writing.
• Experience with aseptic technique and pipetting (desired).
• Experience with working with and maintaining eukaryotic tissue cultures of several immortalized human cell lines and primary cells (desired).
• Experience with assays including cytotoxicity measurements, ELISA, and Western Blotting (desired).
• Task driven.
• Experience with maintaining a laboratory notebook, recording and summarizing experimental results, and communicating data, hypotheses, and experimental approaches (desired).
**Qualifications**
Required Degree(s) in:
• Biological Science
• Chemistry
• Physical Science
• Healthcare
• Psychology
• Related field
**Experience**
Experience Required:
• 12 months (with Bachelor’s Degree)
Other:
• 48 months equivalent experience in lieu of the Bachelor’s Degree for a total of 60 months research experience.
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