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September 13, 2025

**Job Description**
The research project focuses on understanding enzyme promiscuity and engineering enzymes to facilitate novel reactions, aiming to improve the sustainability of the chemical and pharmaceutical industries. The PhD student will employ bioinformatic selection, enzyme production, screening, and protein engineering to develop biocatalysts for new-to-nature reactions. The work involves investigating molecular mechanisms to accelerate the development of further biocatalysts and will ultimately contribute to the creation of practically applicable catalysts for efficient synthesis of societally important molecules.

**Skills & Abilities**
• Strong grasp of and interest in fundamental concepts in organic chemistry
• Enthusiasm in expanding capabilities and passion for learning new wet-lab or dry-lab skills
• Beneficial: Synthetic chemistry
• Beneficial: Site-directed mutagenesis and cloning; protein expression/purification
• Beneficial: Enzyme engineering/evolution; analytical method development
• Beneficial: Protein bioinformatics; computational (bio)chemistry

**Qualifications**
Required Degree(s) in:
• Chemistry
• Biochemistry
• Biotechnology
Other:
• English proficiency at a certain level to ensure effective communication, participation in Doctoral Education courses, and writing scientific articles and a final thesis.

**Experience**
Other:
• Demonstrated ability and passion for learning new wet-lab or dry-lab skills

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Experience
Other: • Demonstrated ability and passion for learning new wet-lab or dry-lab skills
Work Level
Ph.D
Employment Type
Scholarship
Salary
Annual Salary: In accordance with the Collective Labour Agreement for Dutch Universities, increasing gross monthly from the first to the fourth year based on a full-time contract (38 hours). Benefits: 8% holiday allowance, 8.3% end-of-year bonus, customizable compensation package, discounts on health insurance, monthly work costs contribution, flexible work schedules, relocation support via the Coming to Delft Service, and a Dual Career Programme for accompanying partners.
Valid Until
October 26, 2025
Details
Full-time / Temporary Duration: 4 years (initial 1.5 year contract, followed by 2.5 years) Location Requirement: Relocation to the Netherlands may be required
School / Department / Center / Lab
• Research group of Dr. Reuben Leveson-Gower • BOC section • Faculty Applied Sciences • TU Delft Graduate School
Supervisor(s)
Dr. Reuben Leveson-Gower
Supervisor Email
r.m.leveson-gower@tudelft.nl bartjan.schrijver@tudelft.nl
Delft University of Technology (TU Delft)
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