Ph.D. Studentship

**Job Description**
This Ph.D. studentship focuses on the structure and function of the genome within Professor Sir Shankar Balasubramanian’s lab. The project explores fundamental mechanisms of genome function by exploiting both chemistry and biology, with a particular emphasis on alternative nucleic acid secondary structures, specifically four-stranded DNA G-quadruplexes, and chemically modified DNA/RNA bases. These epigenetic features are critical to normal biology and oncogenesis. The student will join a team investigating their formation, dynamics, and functions in the genome, aiming to understand mechanisms regulating gene expression, DNA replication, and genome stability and their impact on cell state changes. The research also involves developing novel methods to investigate genome function, including mapping nucleic acid-interacting drugs and sequencing modified bases.

**Skills & Abilities**
• Highly motivated
• Capable of independent thought
• Excellent communication skills
• Ability to work collaboratively
• Strong background in molecular biology and/or biochemistry (ideal)
• Good knowledge of genomics and the chemistry/chemical biology of nucleic acids (highly desirable)

**Qualifications**
Required Degree(s) in:
• Molecular Biology
• Biochemistry
• Genomics
• Chemistry
• Chemical Biology

**Experience**
Other:
• Recent graduates or final-year undergraduates who hold or expect to gain a First/Upper Second Class degree (or equivalent) in a relevant subject
• Relevant research experience (e.g., Master’s study or laboratory work) is strongly encouraged

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