PhD Position

**Job Description**
This doctoral project, situated in Dr. Redmond Smyth’s laboratory at the Institute of Molecular and Cellular Biology (IBMC), aims to elucidate the role of RNA modifications in viral and cellular RNA during HIV-1 infection. The research will employ advanced RNA biology techniques, including long-read nanopore sequencing and direct RNA sequencing (dRNA-seq). The initial phase of the project will focus on the characterization of N6-methyladenosine (m6A) within the HIV-1 5′ untranslated region (5’UTR), investigating its impact on RNA structure, translation efficiency, localization, and encapsidation. Subsequently, the project will examine how HIV-1 infection influences the host cell’s translation machinery, specifically analyzing alterations in the modification profiles of host tRNAs and rRNAs. This study seeks to bridge significant knowledge gaps concerning RNA modifications in viral replication and host-pathogen interactions, potentially informing new antiviral therapeutic strategies.

**Skills & Abilities**
• Basic French language proficiency

**Qualifications**
Required Degree(s) in:
• Biological sciences
• Medical sciences
• Pharmacological sciences

**Experience**
Experience Required:
• None (Biological sciences)
• None (Medical sciences)
• None (Pharmacological sciences)

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