PhD position in Chemistry with a specialization in biochemistry

**Job Description**
This Ph.D. project focuses on advanced electron microscopy (EM) method development within chemistry, specializing in biochemistry. The research will utilize focused ion beam (FIB), cryo-EM, and electron tomography to visualize the architecture and molecular machinery driving bacterial growth and development, specifically in the filamentous bacterium family of Streptomyces. Key areas include the in vitro assembly of cytoskeleton proteins and the cellular localization of polarisome and divisome protein complexes. The student will combine cryo-EM sample preparation, single-particle and helical 3D reconstruction, and in situ electron tomography to image bacterial multi-protein complexes and understand mechanisms regulating bacterial polarity and cell division. The position involves participation in research and postgraduate courses, with potential for teaching and other departmental work up to 20%.

**Skills & Abilities**
• Strong interest and enthusiasm for biological science, microbiology, and biotechnology
• Practical project experience in molecular biology
• Practical project experience in gene technology
• Practical project experience in protein biochemistry (especially protein purification)
• Practical project experience in computational image analysis
• Fluent in both oral and written English
• Skills and experience in diverse microscopy techniques (especially electron microscopy)
• Skills and experience in computational programming
• Skills and experience in modeling
• Collaborative skills
• Drive and independence

**Qualifications**
Required Degree(s) in:
• Chemistry
• Biochemistry
• Molecular Biology
• Biotechnology Engineering
• Related scientific fields
(Candidates must have completed a second-cycle level degree, or completed course requirements of at least 240 ECTS credits, of which at least 60 ECTS credits are at second-cycle level or equivalent. Specific entry requirements for chemistry include at least 90 ECTS credits in chemistry or a directly relevant subject, with at least 15 ECTS credits at second-cycle level in the specialization or equivalent.)

**Experience**
Other:
• Practical project experiences including molecular biology, gene technology, protein biochemistry (especially protein purification), and computational image analysis must be acquired before starting the Ph.D. project work.

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