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September 11, 2025

**Job Description**
Two PhD positions are available to unravel the molecular mechanisms of virus self-assembly, specifically focusing on how RNA-containing viruses are built. This interdisciplinary project will utilize advanced microscopy and nanomanipulation techniques to record the live construction of viruses at the nanoscale, aiming to provide fundamental understanding of disease-causing agents and inform the development of more efficient antivirals. One position will concentrate on High Speed-Atomic Force Microscopy (HS-AFM) to visualize viral self-assembly and scrutinize protein-protein and protein-nucleic acid interactions. The second position will employ Single Molecule Optical Tweezers (SMOT) to study self-assembly via the compaction force of protein-RNA interactions.

**Skills & Abilities**
• Advanced microscopy
• Nanomanipulation techniques
• High Speed-Atomic Force Microscopy (HS-AFM)
• Single Molecule Optical Twezers (SMOT)
• Interdisciplinary research skills (physics, chemistry, biology)

**Qualifications**
Required Degree(s) in:
• Physics
• Chemistry
• Biology

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Work Level
Ph.D
Employment Type
Scholarship
Details
Full-time / Temporary Duration: 4 years
School / Department / Center / Lab
• Wouter Roos lab • Faculty of Science and Engineering (FSE) • Zernike Institute for Advanced Materials (ZIAM)
Supervisor(s)
Wouter Roos
Supervisor Email
See Details
University of Groningen
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