PhD Project in Tumour Immunity and Immunometabolism

**Job Description**
This PhD project will investigate the tumour immunity cycle, focusing on the cyclical trafficking and interactions of T cell subsets between tumour and lymphoid organs, particularly within the tumour- or tissue-microenvironment. Building on existing collaborations with AstraZeneca, the project aims to explore the role of specific metabolites and a recently discovered chemokine receptor in the migration and positioning of regulatory and ‘stem-like’ CD8 T cells, and their impact on anti-cancer immunity and ICI therapy efficacy in pancreatic cancer. The research will utilize cutting-edge mouse models, immunology expertise, access to relevant patient material, spatial and circulatory metabolomics, and imaging mass cytometry to test the effect of AstraZeneca’s clinical compounds on the immune-metabolic landscape of PanIN-to-PDAC models.

**Skills & Abilities**
• Immunology expertise.
• Experience with mouse models.
• Proficiency in spatial and circulatory metabolomics (or aptitude for training).
• Proficiency in imaging mass cytometry (or aptitude for training).
• Ability to conduct metabolomic and lipidomic analysis (training provided).

**Qualifications**
Other:
• Open to UK citizens.
• Open to overseas students meeting UK residency requirements.
• Open to overseas students able to cover the difference in international fees through additional funding awards.

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