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September 15, 2025

**Job Description**
This project focuses on investigating novel molecular pathways responsible for resolving alternative non-B form DNA structures (such as hairpins, cruciforms, and G-quadruplexes) that can threaten genome integrity and are linked to genetic and neurodegenerative disorders. The research will employ the Xenopus egg extract system, defined DNA templates, biochemical assays, and mass spectrometry to dissect the unfolding mechanisms during DNA replication, aiming to uncover how these structures are detected, processed, and their implications for genome stability and human disease onset.

**Skills & Abilities**
• Highly motivated and independent scientist
• Strong collaborative spirit
• Passion for working in an international research environment
• Background in molecular biology
• Experience in protein biochemistry (advantage)

**Qualifications**
Required Degree(s) in:
• MSc degree (in Biological sciences, Molecular Biology, or a related field)

**Experience**
Other:
• Experience in protein biochemistry is an advantage

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Experience
Other: • Experience in protein biochemistry is an advantage
Work Level
Ph.D
Employment Type
Scholarship
Salary
Annual Salary: €36,708 - €46,572 Position Classification: scale P cao Nederlandse Universiteiten/KNAW Benefits: 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance, and pension accrual with ABP. Excellent package of secondary benefits including the option to increase days off from 29 to 41 days a year (with full-time employment).
Valid Until
October 31, 2025
Details
Full-time / Temporary Brief location description: Campus-based
School / Department / Center / Lab
• Hubrecht Institute
Supervisor(s)
prof. dr. Puck Knipscheer
Supervisor Email
See Details
Royal Netherlands Academy of Arts and Sciences (KNAW)
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