Postdoctoral Research Associate

**Job Description**
The Postdoctoral Research Associate will lead a project focused on ultrasound-mediated brain tumour treatment utilizing drug-loaded liposomes. The role involves understanding therapeutic ultrasound and liposome drug delivery systems, applying in vivo imaging techniques such as MRI and NIRF/luminescence, and possessing skills in chemistry and liposome synthesis. The candidate will be responsible for characterizing liposomes, testing their ability to deliver drugs into brain tumour mouse models, assessing antitumour effects, developing patient-derived organoids for orthotopic injection in mice, and assembling/maintaining ultrasound equipment. The project involves using focused ultrasound and circulating microbubbles to non-invasively disrupt the blood-brain barrier and achieve targeted drug release through mild hyperthermia, with a focus on non-invasive treatment of Glioblastoma.

**Skills & Abilities**
� Good understanding of therapeutic ultrasound
� Knowledge of Liposome drug delivery systems
� Proficiency in in vivo imaging techniques, including magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF)/luminescence imaging
� Skills in chemistry and liposome synthesis
� Analytical chemistry techniques (NMR)
� Analytical chemistry techniques (Mass Spectrometry)
� Analytical chemistry techniques (Fluorimetry)
� Analytical chemistry techniques (HPLC)
� Knowledge of preparing in vivo tumour models
� Good knowledge of preclinical bioimaging
� Experience or knowledge of Bioluminescence and/or PET preclinical imaging
� Experience of ultrasound treatments for cancer therapy
� Knowledge of brain tumour therapy discovery and development (desirable)
� Knowledge of focused ultrasound for brain tumour clinical trials (desirable)
� Knowledge of brain ultrasound principles (desirable)
� Skills of networking and Commercialisation (desirable)
� Knowledge of product development and regulation steps (desirable)

**Qualifications**
Required Degree(s) in:
� PhD in the development of ultrasound drug treatments
� MSc/MRes degree in Pharmacology
� MSc/MRes degree in Nanomedicine
� MSc/MRes degree in Biomedical Engineering

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