**Job Description**
The University of Birmingham is seeking a talented and motivated postdoctoral researcher to join the Croft lab within the Rheumatology Research Group. The successful candidate will work in translational immunology to deliver a specific project focused on understanding the biology of lubricin and its role in fibroblast-macrophage crosstalk within the lining layer of the synovium under healthy resting conditions. This will involve using a combination of synovial tissue organoid systems and transgenic mouse models to delineate the role of proteoglycan-4 in joint homeostasis. The researcher will collaborate with other lab-based scientists, computational biologists, and external partners.
**Skills & Abilities**
• High level analytical capability
• Broad understanding of next generation sequencing (NGS) technologies
• Proven experience in analysis of bulk and single cell transcriptomic data (advantage)
• Ability to communicate complex information clearly
• Ability to write to a standard required for research reports/publications
• Effective interpersonal and communication skills
• Ability to interact with project partners and explain complex ideas to non-bioinformaticians in an understandable way
• Ability to work in a heterogeneous environment of Clinicians, Biologists and Bioinformaticians
• Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
• Knowledge of bioinformatics resources such as annotation tools and databases
• Proficiency in R/BioConductor and High Level (e.g. python) programming languages
• Proficiency in Databases (SQL)
• Proficiency in development and maintaining code repositories (version control)
• Ability to assess resource requirements and use resources effectively
• Ability to learn and keep abreast of latest technological, methodological and software developments
• Understanding of, and ability to contribute to, broader management/administration processes
• Ability to plan and organise the research programme and/or specific research project
• Ability to co-ordinate own work with others to avoid conflict or duplication of effort
• Knowledge of the protected characteristics of the Equality Act 2010
**Qualifications**
Required Degree(s) in:
• Immunology
• Basic or Translational Immunology (PhD or near to completion)
**Experience**
Other:
• Background in synovial fibroblast and macrophage biology, ideally having studied lubrication biology in the joint
• Experience in molecular biology, computational immunology, bioinformatics and multi-dimensional imaging including light-sheet and 3D tissue imaging
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